Lonomia obliqua venom and hemolymph have been shown to contain molecules that, besides interfering in blood coagulation (for a review, Veiga et al. ). Lonomia obliqua (Walker, ) is a moth from the family Saturniidae, widely distributed in tropical rainforests of South America. In its larval stage (caterpillar) it . Rev Assoc Med Bras (). May-Jun;61(3) doi: / Lonomia obliqua Walker (Lepidoptera: Saturniidae): hemostasis .
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Quite interestingly, we found that the antiapoptotic protein isolated from L. It is worthy to note that all patients evolved favorably within the first few hours, and for this reason, the use of this antivenom is recommended to treat the lnomia of Lonomia erucism in Argentina.
P values less or equal to 0. Saturniidaewere described. Your comment will be reviewed and published at the journal’s discretion.
[Accidents with caterpillar Lonomia obliqua (Walker, 1855). An emerging problem].
Accidental contact lonnomia caterpillar’s bristles induces allergic and toxic signs and symptoms that range from mild cutaneous reaction to severe systemic reactions, depending mainly on the number and species of the caterpillar involved. Growth inhibition and radiosensitization of cultured glioma cells by nitric oxide generating agents. In other projects Wikimedia Commons Wikispecies.
Shortly after admission, her coma was rated as Glasgow 3. She was discharged on the ninth day of hospitalization with creatinine The first step to verify this difference would be to identify the cellular mechanism activated in fibroblasts that lead these cells to death and try to determine if this same mechanism is activated or not in tumor cells treated with the venom.
It was discovered that the toxin in the caterpillar’s skin held potent anti-clotting agents. Most countries do not stock this product. This accounts for the minimum of deaths resulting from contact with L. A diagnosis of Lonomia oblqiua poisoning and subsequent acute kidney injury AKI and coagulopathy was made.
All experiments were performed at least three times.
oblqua Its hair growth covers its body, and each clump of spines is able to easily puncture the skin and release toxins into the victim. Lonomia obliqua venom and hemolymph have been shown to contain molecules that, besides interfering in blood coagulation for a review, Veiga et al. These results suggest that the venom components act at different optimal concentrations, therefore the combined effect may vary depending on sample preparation, concentration used and also cell type.
Ceramide in nitric oxide inhibition of glioma cell growth. The increase in cell number could be clearly observed under light microscopy Fig. Nevertheless, one cannot disregard that the joint action of some active principles of the venom, such as the hemolytic activity of PLA2 and the hyaluronidase activity, may have inhibitory effect on proliferation and cell viability.
The poison only takes effect in fairly large amounts; in order to experience the extreme effects caused by the toxins, a human victim would probably need to be stung at least 20 to times because each sting only injects a minute amount of venom.
On the other hand, crude venom extract displayed a strong cytotoxic effect on the V lineage, inhibiting the viability of these cells. Author information Article notes Copyright and License information Disclaimer. Enhancement of Sf-9 obilqua growth and longevity through supplementation of culture medium with loonmia. Accordingly, our results show that the venom increases the viability of tumor cells and decreases the lonomja of fibroblasts, which may be due to molecular differences between cell types.
To verify if the venom induced an increase in the number of viable cells even in the absence of growth factors and other components present in serum, cells were first grown in quiescent conditions and then treated with 0. The findings of blood tests on arrival were Hb 9.
[Accidents with caterpillar Lonomia obliqua (Walker, ). An emerging problem].
Blood coagulation and fibrinolytic factors in patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Obliiqua Catarina, southern Brazil. When travelling to endemic zones in Central and South America, travellers should be aware of poisonous caterpillars and avoid direct contact.
Production of recombinant protein therapeutics in cultivated mammalian cells. The basic constitution of the venom is protein and its components produce physiological changes in the victim, which include disturbances in hemostasis.
This article was originally published in. It is known that, in gliomas, nitric oxide displays dual pro- and antitumor action, depending on the site and concentration of the molecule. This reaction occurs only when the mitochondrial reductase enzymes are active in living cells; thus, the conversion of MTT to formazam crystals is used to determine viable cells.
Lonomia obliqua Walker (Lepidoptera: Saturniidae): hemostasis implications.
Latest Most Read Most Cited Screening questions for the oobliqua of restless legs syndrome in hemodialysis. Lonomia obliqua Lepidoptera, Saturniidae ; 6 th instar larvae. Coagulation factors tend to be more profoundly altered in all patients with AKI in keeping with these being more severe cases.
Specific laboratory tests for diagnosis of poisoning have not been described previously. Exposure of cells to L. This mechanism also occurs in normal cells, in which proliferation is well regulated, which does not occur in tumor cells.